|
Colorectal Carcinoma
|
0.510 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Pancreatic Ductal Adenocarcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
melanoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Moreover, our findings show that ABCB5 is a novel molecular marker for a distinct subset of chemoresistant, stem cell phenotype-expressing tumor cells among melanoma bulk populations and indicate that these chemoresistant cells can be specifically targeted via ABCB5 to enhance cytotoxic efficacy.
|
15899824 |
2005 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
In serial human-to-mouse xenotransplantation experiments, ABCB5+ melanoma cells possess greater tumorigenic capacity than ABCB5- bulk populations and re-establish clinical tumour heterogeneity.
|
18202660 |
2008 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
We identified and cloned two novel mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ABC transporter ABCB 5 in human melanoma cells.
|
15760339 |
2005 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Electrocardiogram: P-R interval
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
|
24324551 |
2013 |
|
Colorectal Carcinoma
|
0.510 |
Biomarker
|
disease |
CTD_human |
The role of ABC transporters in progression and clinical outcome of colorectal cancer.
|
22294766 |
2012 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Moreover, our findings show that ABCB5 is a novel molecular marker for a distinct subset of chemoresistant, stem cell phenotype-expressing tumor cells among melanoma bulk populations and indicate that these chemoresistant cells can be specifically targeted via ABCB5 to enhance cytotoxic efficacy.
|
15899824 |
2005 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
The role of ABC transporters in progression and clinical outcome of colorectal cancer.
|
22294766 |
2012 |
|
Colorectal Carcinoma
|
0.510 |
Biomarker
|
disease |
BEFREE |
Our results implicate ABCB5 as a critical determinant of CRC invasiveness and suggest that ABCB5 blockade might represent a strategy in CRC therapy, even independently of ABCB5's function as an MDR mediator.
|
29789423 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Studies in four melanoma cell lines with various genetic backgrounds showed an increase in the proliferation and migration capacity of mutant ABCB5-expressing cells, suggesting that ABCB5 plays a role in the development of melanoma as a tumor suppressor gene.
|
30905807 |
2019 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This is the first study showing the relationship between miR-340-5p and expression of ABCB5, a transmembrane transporter involved in drug resistance considered as a marker of melanoma stem-like cells.
|
26554847 |
2015 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vivo, melanoma-specific shRNA-mediated knockdown of VEGFR-1 blocked the development of ABCB5(+) VM morphology and inhibited ABCB5(+) VM-associated production of the secreted melanoma mitogen laminin.
|
21212411 |
2011 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, definitive markers for the purification and further characterization of melanoma-initiating cells remained elusive.Recently, Schatton et al. provided solid evidence that the doxorubicin-resistant ATP-binding cassette transporter ABCB5 marks primitive cells capable of recapitulating melanomas in xenotransplantation models.
|
18328422 |
2008 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
ATP binding cassette subfamily B member 5 (ABCB5) has been identified as a tumour-initiating cell marker and is expressed in various malignancies, including melanoma.
|
28940439 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Selected anti-clonogenic compounds might be further investigated as potential adjuvants targeting melanoma stem-like cells in the combined anti-melanoma therapy, whereas selected cytotoxic but not anti-clonogenic compounds, which increased the frequency of ABCB5-positive cells and remained slow-cycling cells unaffected, might be considered as a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.
|
24595456 |
2014 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of ABCB5 expression reduces melanoma cell migration and invasion in vitro and melanoma pulmonary metastasis in tumor xenograft mice.
|
28821433 |
2017 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The transmembrane protein ABCB5 is closely linked to tumorigenicity, progression and disease recurrence of diverse human malignancies, including melanoma.
|
30941990 |
2019 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ABCB5 transmembrane protein was tested due to its well-known role in the initiation, invasion and metastatic spread of various cancers, including melanoma.
|
28704989 |
2019 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of this study is to determine whether ABCB5 is highly expressed in BRAF inhibitor-resistant melanoma cells and to evaluate whether ABCB5 is involved in the development of resistance to BRAF inhibitors in cutaneous melanoma.
|
29929490 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although neither of these two genes have been previously associated with sarcoma, ABCB5 has been shown to share clinical drug resistance associations with melanoma and leukaemia and C16orf96 shares regulatory elements with genes that are involved with TNF-alpha mediated apoptosis in a p53/TP53-dependent manner.
|
31053105 |
2019 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Flow cytometry and immunofluorescence analysis indicated that sphere-derived cells contained a smaller proportion of cells expressing the candidate surface markers of melanoma stem cells such as ABCB5, CD133, CD20 and CD271, and a larger proportion of cells expressing melanocytic differentiation markers such as HMB45 and S100 protein, compared with adherent cells.
|
23752306 |
2013 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
At the molecular level, we show that melanoma Rh123(low) cells overexpress HIF1α, pluripotency factor OCT4, and the ABCB5 marker of melanoma stem cells and downregulate the expression of Cyclin D1 and CDK4.
|
23355370 |
2013 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the helicase HAGE has a key role in the resistance of ABCB5+ MMICs to IFNα treatment and that cancer therapies targeting HAGE may have broad implications for the treatment of malignant melanoma.
|
24525737 |
2014 |